Factors that Affect Melanoma Prognosis

Melanoma is a disease in which malignant (cancer) cells form in the skin cells called melanocytes. Melanocytes are found throughout the lower part of the epidermis. They make melanin, the pigment that gives skin its natural color. When skin is exposed to the sun, melanocytes make more pigment, causing the skin to tan, or darken.

The skin is the body’s largest organ. It protects against heat, sunlight, injury, and infection. The skin has 2 main layers: the epidermis and the dermis. When melanoma starts in the skin, the disease is called cutaneous melanoma. Melanoma may also occur in the eye and is called intraocular or ocular melanoma. There are 3 types of skin cancer are melanoma, basal cell skin cancer and squamous cell skin cancer.

Melanoma is more aggressive than basal cell skin cancer or squamous cell skin cancer. Melanoma can occur anywhere on the body. In men, melanoma is often found on the trunk or the head and neck. In women, melanoma often develops on the arms and legs. Melanoma usually occurs in adults, but it is sometimes found in children and adolescents.

Unusual moles, exposure to sunlight, and health history can affect the risk of developing melanoma. Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. People who think they may be at risk should discuss this with their doctor.

Risk factors for melanoma include the following: unusual moles, exposure to natural sunlight, exposure to artificial ultraviolet light (tanning booth), family or personal history of melanoma, being white and older than 20 years, red or blond hair, white or light-colored skin and freckles, blue eyes, and so on.

Possible signs of melanoma include a change in the appearance of a mole or pigmented area. These and other symptoms may be caused by melanoma. Other conditions may cause the same symptoms. A doctor should be consulted if a mole changes in size, shape, or color, has irregular edges or borders, change in pigmented skin, and so on.

Tests that examine the skin are used to detect and diagnose melanoma. If a mole or pigmented area of the skin changes or looks abnormal, the following tests and procedures can help detect and diagnose melanoma. Skin examination: A doctor or nurse examines the skin to look for moles, birthmarks, or other pigmented areas that look abnormal in color, size, shape, or texture.

Biopsy: A local excision is done to remove as much of the suspicious mole or lesion as possible. A pathologist then looks at the tissue under a microscope to check for cancer cells. Because melanoma can be hard to diagnose, patients should consider having their biopsy sample checked by a second pathologist. Suspicious areas should not be shaved off or cauterized.

Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis and treatment options depend on the stage of melanoma, whether there was bleeding or ulceration at the primary site, the location and size of the tumor, and the patient’s general health. Although many people are successfully treated, melanoma can recur.

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